– OBJECTIVE: Subthalamic stimulation has become the procedure of choice in most cases of Parkinson’s Disease. This article describes subthalamic nucleus coordinates on human anatomical material, to infer the likely location of the target on the patient’s brain.
– METHODS: The material consisted of 25 coronal brain slices stained using Mulligan’s method. A total of 40 subthalamic nuclei were identified and their dimensions were measured. The position of subthalamic nuclei related to the midline, cerebral cortex and red nucleus (RN) was evaluated.
– RESULTS: The major axis length of STN was 10.06 mm (standard-deviation [SD] 1.03 mm) on average and minor axis length was 3.08 mm (SD 0.55 mm). The STN lies at a mean angle of 49.56o (SD, 3.01o) to the midline. The central point is 13.22 mm (SD 0.49 mm) to the midline, 2.23 mm (SD 0.26 mm) inferior to the superior border of RN and 2.89 mm (SD 0.27 mm) lateral to the most lateral border of RN.
– CONCLUSION: Subthalamic nucleus has constant anatomical relationships with red nucleus and midline, thus permitting their use in the calculus of stereotaxic coordinates for surgery.